Effect of JNJ 31001074 on Urge to Drink in Alcohol-Dependent Adults

• Status: Withdrawn
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess whether JNJ-31001074 taken for 7 days reduces the urge to drink alcohol in alcohol-dependent study participants who are not seeking treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Janssen Research & Development, LLC
• Collaborator: The Scripps Research Institute
• Treatments: Ethanol

Criteria

Inclusion Criteria:

• Male or female

• Currently alcohol dependent but not seeking treatment

• Meets study criteria for amount of alcohol consumed

• Otherwise healthy

• Urge to drink increased by the presence of alcohol

• Able to complete and understand questionnaires and study procedures in English

• Willing and able to comply with the study requirements, including a 3-day period of alcohol abstinence and use of highly effective contraceptive methods

• Signed informed consent.

Exclusion Criteria:

• Pregnant or breast-feeding

• Significant medical or psychiatric conditions other than alcohol dependence

• History of, or at risk of, medically significant alcohol withdrawal syndrome

• Dependent on substances other than alcohol , nicotine or caffeine

• Smokes more than 1 pack of cigarettes per day or consumes more than 500 mg caffeine per day

• Has glaucoma, cataracts, a history of eye inflammation, eye injury, or eye surgery other than to correct vision

• Treatment in the past 1 month prior to screening with disulfiram (Antabuse), acamprosate (Campral), naltrexone (ReVia or Vivitrol), or topiramate (Topamax)

• In need of or currently taking any psychoactive medications