Effect of Itraconazole on the Pharmacokinetics of SHR6390 in Healthy Subjects
Status:
Completed
Trial end date:
2021-02-02
Target enrollment:
Participant gender:
Summary
The primary objective of the study is to evaluate the effect of itraconazole on
pharmacokinetics of healthy Chinese adult subjects after oral administration of SHR6390
tablets. The secondary objective of the study is to evaluate the safety of SHR6390 alone and
when co-administered with itraconazole. The exploratory objective of the study is to explore
the effect of SHR6390 related metabolic enzymes and transporter gene polymorphisms on the
pharmacokinetics of SHR6390.