Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine Isoflurane's dose-dependent effect on left ventricular (LV) systolic function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular systolic velocity at three different isoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Konkuk University Medical Center
• Treatments: Isoflurane; U 78517F

Criteria

Inclusion Criteria:

• patients undergoing cardiac surgery

Exclusion Criteria:

• low ejection fraction < 50% in preoperative transthoracic echocardiography

• atrial fibrillation

• pacemaker

• pericardial and infiltrative myocardial disease

• mitral annular calcification, surgical rings, prosthetic mitral valves

• lateral left ventricular regional wall motion abnormality

• esophageal spasm, stricture, laceration, perforation, and diverticulum diaphragmatic hernia

• history of extensive radiation to mediastinum

• upper gastrointestinal bleeding