Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery

• Status: Not yet recruiting
• Trial end date: 2023-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Patients undergoing elective non-cardiac surgery under general anesthesia

• ASA physical status II-III

• Aged ≥65 years

Exclusion Criteria:

• Serious heart, lung, liver and kidney diseases

• Central nervous system injury

• Mental illness and drug dependence

• On regular use of analgesic/sedative/antidepressant

• Unable to cooperate

• Allergy to lidocaine

• MMSE < 23 points