Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain

• Status: Unknown status
• Trial end date: 2018-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

*Aim of the Work This study aims to assess the efficacy of intravenous injection of dexamethasone prior to spinal anesthesia in reducing post-cesarean section pain in women undergoing cesarean section.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams Maternity Hospital
• Collaborator: Ain Shams University
• Treatments: Anesthetics; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

• Inclusion Criteria:

• A gestational age of 38 weeks or more and planned for elective cesarean section.

• Living fetus.

• Any number of previous cesarean section.

• Intact amniotic membranes.

• No history of bleeding tendency.

• Exclusion Criteria:

• Refuse to participate after counseling.

• Contraindication to spinal anesthesia (coagulopathy significant hypovolemia systemic or local sepsis - increased intracranial pressure - local anesthetic or fentanyl allergy).

• High risk pregnancies as pre-eclampsia, any medical disorder (diabetes mellitus, cardiac disease or and thyroid disease).

• Contraindication to corticosteroids e.g. systemic fungal infection

• Steroid medication one week before the operation.

• Chronic pain or daily intake of analgesic.

• Abnormal placentation e.g. placenta previa.

• Intrauterine infection.