Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sorlandet Hospital HF
• Treatments: Ceftriaxone; Doxycycline

Criteria

Inclusion Criteria:

• Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:

• Intrathecal production of borrelia antibodies;

• White cell count in cerebrospinal fluid (CSF) > 5/mm3;

• Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;

• Verified acrodermatitis chronica atrophicans.

Exclusion Criteria:

• Allergy to the contents in the medication, or earlier type I reaction to penicillin.

• Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days

• Pregnancy or breastfeeding

• Age < 18 years