Effect of Intrauterine Injection of HCG on Pregnancy Outcome in Repeated Implantation Failure Patients
Status:
Withdrawn
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
Repeated implantation failure（RIF） is a insurmountable bottleneck in assisted reproductive
technology, many studies have considered that the cause of two-thirds of implant failure is
the decreased endometrial receptivity. Human chorionic gonadotropin (hCG) is an early
pre-plant signal molecule secreted by the embryo, it can promote endometrial proliferation,
increase blood flow and promote embryonic adhesion and inhibit self-regulate apoptosis of
trophoblast cells. Previous studies showed that: intrauterine injection of HCG before embryo
transfer can improve clinical outcomes in IVF/Intracytoplasmic sperm injection(ICSI). But
some studies found that the intrauterine injection of HCG can not significantly improve the
success rate of blastocyst transfer, and the reason may be the intrauterine injection of HCG
time is too late to significantly increase the implantation rate. Would ahead of intrauterine
injection of HCG be more effective? Thus, the patients of repeated implantation frozen embryo
cycle according to the random principle accepted two kinds of transplants ways: ①intrauterine
injection of HCG before blastocyst transfer; ②blastocyst transfer. Try to understand whether
intrauterine injection of HCG can significantly improve the clinical pregnancy rate of
blastocyst transfer in repeated implantation failure patients.