Effect of Intrauterine Injection of HCG on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients
Status:
Completed
Trial end date:
2019-10-16
Target enrollment:
Participant gender:
Summary
Repeated implantation failure（RIF） is a insurmountable bottleneck in assisted reproductive
technology, many studies have considered that the cause of two-thirds of implantation failure
is the decreased endometrial receptivity. After exclude some major local immune
factors(NK,CD138 cells) and implantation window out of phase, There are still a part of
patients infertile .Human chorionic gonadotropin (hCG) is an early pre-implantation signal
molecule secreted by the embryo, it can promote endometrial proliferation, increase blood
flow and promote embryonic adhesion and inhibit self-regulated apoptosis of trophoblast
cells. Previous studies showed that: intrauterine injection of HCG before embryo transfer can
improve clinical outcomes in IVF/Intracytoplasmic sperm injection(ICSI). But some studies
found that the intrauterine injection of HCG can not significantly improve the success rate
of blastocyst transfer, and the reason may be the intrauterine injection of HCG time is too
late to significantly increase the implantation rate. Would ahead of intrauterine injection
of HCG be more effective? Thus, the patients of repeated implantation frozen embryo cycle
according to the random principle accepted two kinds of transplants ways: ①intrauterine
injection of HCG before blastocyst transfer; ②blastocyst transfer. Try to understand whether
intrauterine injection of HCG can significantly improve the clinical pregnancy rate of
blastocyst transfer in repeated implantation failure patients.