Effect of Intrathecal Neostigmine on Post-dural Puncture Headache.
Status:
Not yet recruiting
Trial end date:
2023-05-17
Target enrollment:
Participant gender:
Summary
Intravenous neostigmine was recently reported as an effective treatment for PDPH for
parturients after intrathecal (IT) block which is postulated to be through its central
effects on CSF secretion and cerebral vascular tone modulation. Intrathecal neostigmine has
been investigated widely and found to be an effective adjuvant to bupivacaine for
postoperative analgesia.
The objective of the current study is to investigate the possible prophylactic role of
intrathecal neostigmine as an adjuvant to bupivacaine in reducing the incidence and severity
of post-dural puncture headache in parturients scheduled for an elective cesarean section.