Effect of Intraoperative Magnesium Infusion on Postoperative Pain and Cognitive Function

• Status: Recruiting
• Trial end date: 2020-04-15
• Target enrollment: 0
• Participant gender: All

Summary

The aimof this study is to observe the effect of intraoperative magnesium infusion on peri-operative pain and postoperative cognitive functions in adult patients after elective pelvi-abdominal surgeries.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

1. Male and female patients (age 20-60 years)

2. American Society of Anesthesiology(ASA) physical status I-II

3. Patients scheduled for elective pelvi-abdominal surgeries

Exclusion Criteria:

1. Patients having significant cardiovascular (cardiomyopathy or moderate to severe valvular heart lesion) , significant hepatic disease (Child-Pugh score B or C ), renal or CNS disease

2. Patients with uncontrolled hypertension or diabetes

3. History of hypersensitivity to the drugs to be used

4. Control MMSE score ≤23

5. Women who are pregnant or breastfeeding

6. Patients taking Ca2+ channel blockers, opioids, antidepressants, or antipsychotics or alcohol

7. Patients having difficulty understanding , vision or hearing problems or CNS disorder as parkinson's disease .

8. Morbidly obese patients with a body mass index of >40

9. Patients who refused to be involved within the scope of the research.