Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury

• Status: Completed
• Trial end date: 2017-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the renal protective effect of dexmedetomidine in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gangnam Severance Hospital
• Treatments: Anesthetics; Dexmedetomidine

Criteria

Inclusion Criteria:

• Diagnosis of malignant tumor with peritoneal metastasis

• Scheduled for elective cytoreduction and hyperthermic intraperitoneal chemotherapy

Exclusion Criteria:

• Preoperative chronic kidney disease stage ≥4 defined by KDOQI ( eGFR < 30 mL/min/1.73m2)

• Congestive heart failure

• Atrioventricular block > 1st degree

• Bradycardia < 45 beat per minute

• History of myocardial infarction within 3 months

• Pregnancy