Effect of Intraoperative Controlled Release 5-Fluorouracil Therapy on Recurrence in Hepatocellular Carcinoma Patients

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to confirmed the role of intraoperative controlled release 5-Fluorouracil therapy in the prevention of recurrence after surgery for HCC patients with high risk of preoperative prediction of microvascular invasion.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eastern Hepatobiliary Surgery Hospital
• Treatments: Fluorouracil

Criteria

Inclusion Criteria:

1. Male or female patients > 18 years and <=70 years of age

2. Patients preoperatively diagnosed of hepatocellular carcinoma according to the criteria of American Association for the Study of Liver Diseases(AASLD)

3. Within Milan criteria

4. Nomogram score for MVI prediction >200

5. Preoperative ECOG criteria score of 0-1

6. Child-Pugh class A liver function

7. No Anticancer treatment before surgery

Exclusion Criteria:

1. Major portal/hepatic vein invasion

2. Extrahepatic metastasis

3. Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction,which may affect the treatment of liver cancer

4. Lost to follow-up

5. Patients participating in other clinical trials

6. Patients refused to join our trial

7. Pregnant and breast-feeding women