Effect of Intraoperative Aprotinin Administration on Post Cardiac Surgery Optic Nerve and Retinal Thickness.

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Cognitive and neurological dysfunction after coronary artery bypass surgery (CABG) is common and multi-factorial in origin. Several previous studies have shown that intraoperative aprotinin administration may be neuroprotective.in the current prospective randomized study, the effect of intraoperative aprotinin administration on the integrity of the optic nerve and retinal nerve fiber layer will be examined. Optical coherance tomography will be used to examin the optic nerve and retinal nerve fiber layer.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Soroka University Medical Center
• Treatments: Aprotinin

Criteria

Inclusion Criteria:

• patients admited for coronary artery bypass surgery

Exclusion Criteria:

Preoperative:

• Patients requiring concomitant noncoronary procedures.

• Urgent operation.

• Intra aortic balloon pump

• Presence of allergy to aprotinin or bleeding diathesis.

• Previous CVA.

• Previous eye operation.

• Glaucoma.

• Retinopathy.

Postoperative:

• Postoperative CVA.

• Postoperative critical condition precluding safe performance of OCT examination.