Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Men and Women
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Exciting advances have led to the concept that hormones can modulate appetite and food
intake. Oxytocin is a peptide hormone that is released in regions throughout the brain,
including areas involved in food motivation. Animal studies suggest that oxytocin may reduce
food intake. The effects of oxytocin administration on eating behavior in humans, which could
have important implications in eating-related disorders ranging from obesity to anorexia
nervosa, have not been investigated. This double-blind placebo-controlled cross-over study of
single-dose oxytocin administration investigates whether:
1. Caloric intake will decrease following administration of oxytocin versus placebo
2. Appetite will decrease following administration of oxytocin versus placebo
3. Resting energy expenditure will increase following administration of oxytocin versus
placebo