Effect of Intracameral Steroids During Phacoemulsification on the Cornea

• Status: Completed
• Trial end date: 2020-08-15
• Target enrollment: 0
• Participant gender: All

Summary

Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.

Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Collaborator: Beni-Suef University
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• Cataract grades 2 to 5 nuclear cataract (LOCS III scale)

• uneventful phacoemulsification operation

Exclusion Criteria:

• extremely hard cataract grade 6 nuclear cataract (LOCS III scale)

• soft cataract

• subluxated lenses or zonular dehiscence

• associated ocular pathology such as glaucoma

• any signs of uveitis

• trauma

• retinal detachment

• vitrectomized or silicone filled eyes

• corneal disease such as Fuch's dystrophy, corneal opacity

• previous refractive corneal surgery

• Cases that developed ruptured posterior capsule and vitreous loss

• those lost to follow up were excluded and randomly replaced by the next chronological patient