Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults
Status:
Completed
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
GLP-1 is an agent for treatment of type 2 diabetes and may have protective effects on the
cardiovascular system. The mechanism is complex and there seems to be a dual function with
intact GLP-1 (7-36), acting through the GLP-1 receptor, and the GLP-1 (9-36) metabolite
acting independently of the GLP-1 receptor.
Coronary flow reserve (CFR) is the ratio of flow through the coronary arteries during stress
to during rest and it reflects coronary microcirculation. Impaired CFR is a strong predictor
of poor prognosis of cardiovascular disease.
The aim of the study is to investigate the acute effects of GLP-1 on coronary
microcirculation and endothelial function in adults with obesity.