Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

• Status: Unknown status
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital
• Treatments: Anesthetics; Atracurium; Cisatracurium; Etomidate; Fentanyl; Midazolam; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Aged between 18 and 65 years;

• Diabetic patients preparing for elective surgery;

• Body mass index is between 16 and 30 kg/m2;

• Blood glucose is under 8.3 mmol/kg by oral antidiabetic agents or diet control;

• American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ;

• Expected operation duration is between 2 and 8 h;

• Signed informed consent form.

Exclusion Criteria:

• Severe cardiac, cerebral, liver, kidney, lung, endocrine disease or infectious disease;

• Chemotherapy or immunotherapy before the surgery;

• Allergy to trial drug or other contraindication;

• Expected or history of difficult airway;

• Suspected abuse of narcotic analgesia;

• Diseases of neuromuscular system;

• Mentally unstable or has a mental illness;

• Trend of malignant hyperthermia;

• Pregnant or breast-feeding women;

• Attendance of other trial past 30 days.