Effect of Increased Free Fatty Acids on Leptin Function
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Obese people have elevated levels of the hormone leptin. Despite this, they seem to be
resistant to the effects of this hormone, which usually regulates appetite and energy
expenditure. This is similar to what happens with insulin levels in the obese. Furthermore,
the way lipid ingestion versus lipid infusion may impact novel molecules secreted by tissues
commonly affected in insulin resistant states such as liver and muscle have not yet been
studied.
The aim of the present study is to investigate the effect of oral vs. different doses of IV
lipid administration on molecular parameters related to glucose and energy homeostasis using
a randomized, placebo-controlled design.
Additionally, we will examine how increased free fatty acids (FFAs) my impact intracellular
leptin signaling such as the STAT3 pathway.