Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH.

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to evaluate the effect of increased circulating androgens on estradiol production by the granulosa cells in response to FSH stimulus.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Diego
• Treatments: Androgens; Letrozole

Criteria

Inclusion Criteria:

• Subjects will be determined to have PCOS based on clinical criteria such as history of irregular menses and clinical or laboratory evidence of hyperandrogenism.

• Subjects should not have been on any hormonal therapy or metformin for at least 2 months prior to study start.

Exclusion Criteria:

• Women with hemoglobin less than 11gm/dl at screening evaluation.

• Women with untreated thyroid abnormalities

• Pregnant women

• Women with BMI>37

• Women with known sensitivity to the agent being used.