Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Status:
Completed
Trial end date:
2007-11-01
Target enrollment:
Participant gender:
Summary
Recent studies have found that poor oral hygiene may foster the colonization of the
oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care
unit (ICU) patients. Thus, improvements in oral hygiene in MV-ICU patients may prevent
ventilator-associated pneumonia (VAP).
The specific aims of this investigation are: 1) to organize the necessary infrastructure to
develop and perform a pilot clinical trial to evaluate alternative oral hygiene procedures to
prevent VAP; 2) to use this organization to perform a pilot clinical trial to determine if
the use of oral topical chlorhexidine gluconate (CHX) will prevent dental plaque,
oropharyngeal colonization by respiratory pathogens, and VAP in MV-ICU patients.
Phase:
Phase 2
Details
Lead Sponsor:
State University of New York at Buffalo
Collaborator:
National Institute of Dental and Craniofacial Research (NIDCR)