Overview

Effect of Immunosuppressants With Adalimumab Biosimilars vs Corticosteroids on Noninfectious Uveitis

Status:
ACTIVE_NOT_RECRUITING

Trial end date:
2026-05-01

Target enrollment:

Participant gender:

Summary

This is a multi-center, prospective, randomized controlled non-inferior clinical study. A total of 120 subjects with non-infectious intermediate, posterior, or panuveitis were enrolled in Zhongshan Ophthalmic Center and three other centers. They were randomly assigned to the experimental group and the control group according to ( 1 : 1 ). We hypothesized that adalimumab biosimilars combined with immunosuppressive agents in the treatment of non-infectious uveitis is not inferior to glucocorticoids combined with immunosuppressive agents, and there are no additional adverse events and safety issues.

Phase:

Details

Lead Sponsor:

Zhongshan Ophthalmic Center, Sun Yat-sen University

Collaborators:

Shandong Eye Hospital
Shenzhen Eye Hospital
The Eye Hospital of Wenzhou Medical University
The First Affiliated Hospital of Soochow University

Treatments:

Adrenal Cortex Hormones
Immunosuppressive Agents