Effect of Iloprost on Pulmonary Oxygenation in Patients With Low Diffusing Capacity During One-lung Ventilation
Status:
Completed
Trial end date:
2017-06-30
Target enrollment:
Participant gender:
Summary
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary
shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far,
hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is
a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery
resistance by selectively dilating pulmonary artery. In this prospective, randomized, double
blind study, investigators are planning to investigate the effects of iloprost on respiratory
physiology (intrapulmonary shunt, deadspace, oxygenation, etc).