Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether paracetamol, ibuprofen or their combination can modify generation of radical oxygen species (ROS) from stimulated neutrophils.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ullevaal University Hospital
• Collaborator: University of Oslo
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Volunteers of both sexes (ASA type I).

• Females who are not pregnant or plan conception. (A pregnancy test will be conducted before each test day)

• Persons who have not used analgesics for 3 days prior to the blood sampling.

• Persons without known active peptic ulcer or gastrointestinal bleeding.

• Persons without any known hypersensitivity for NSAIDs.

• Persons under no other drug treatment than contraceptives.

• Age 18 to 35 years of Caucasian origin

Exclusion Criteria:

• Pregnancy during the test period.

• Development of active peptic ulcer during the test period.

• Change in medication status during the test period (after inclusion).