Effect of Hypertonic Saturated Saline Mouth Rinse on Covid-19 Virus in Vivo.
Status:
Not yet recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Sars-Cov2 virus is transmitted through the respiratory route and by direct contact with
contaminated surfaces and subsequent contact with nasal, oral or ocular mucosa. Many studies
have found that the oral cavity and specifically the saliva may be a high-risk route for
SARS-CoV-2 infection. Thus, strategies reducing salivary viral load could contribute to
reduce the risk of transmission. Furthermore, studies have shown that SARS-CoV persists for
two days in oral mucous membranes before its diffusion to the lower respiratory tract. This
offers an interesting preventive and therapeutic window of opportunity for the control of
this disease. In addition, Naso-pharyngeal viral load was linked with lung disease severity
in a study of 12 patients with pneumonia.**. Some current studies around the world, as listed
on ClinicalTrials.gov, are testing the effect of some common mouth rinses/gargles on the
Covid-19 viral load, including Chlorhexidine gluconate, Hydrogen peroxide Povidone Iodine,
Saline (1.102% w/v, slightly hypertonic) and Alcohol.
This study aims to test whether Prolonged Hypertonic Saline Mouth Rinse would
reduce/eliminate*** the viral load in the Oro- Naso-Pharyngeal cavity, and could therefore be
used as a strategy to reduce transmission risk in clinical and social settings.
The investigator hypothesizes that COVID-19-positive participants who use Hypertonic Saline
Prolonged Rinse treatment will have an reduction/elimination of their Covid viral load, will
develop a negative Covid test 7 days after intervention completion and will improve their
clinical symptoms, potentially reducing lung disease severity.