Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
Status:
Completed
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
During July 2019 to August 2020, a single-blind clinical trial was done to 36 patients with
Graves' disease. At the beginning of the study, subjects were accommodated into 2 groups, 17
into PTU groups and 19 into methimazole groups. There were 24 subjects who finished the
study, 13 from PTU group and 11 from methimazole group. Blood serum was collected for
HOMA-IR, LDL-R, NFĸB, sICAM-1, sVCAM-1 and sE-selectin examination. Meanwhile stiffness and
thickness of carotid artery was measured using PWV and cIMT.