Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
Prospective, controlled, randomized crossover volunteer study to investigate the effect of
hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on
blood coagulation, especially platelet function, as measured by thrombelastography. According
to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by
means of reactive oxygen species. This study aims at investigating a possible pro-coagulant
effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are
integrated.
- Trial with medical device