Overview

Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

Status:
Recruiting
Trial end date:
2022-10-12
Target enrollment:
0
Participant gender:
All
Summary
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Virginia
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatments:
Insulin
Insulin, Globin Zinc
Octreotide
Criteria
Inclusion Criteria:

- Healthy with no chronic illness

- Age 18-35

- Normal BMI (18-25)

- Normal screening labs or no clinically significant values

Exclusion Criteria:

- First degree relative with Type 2 Diabetes

- Smoking presently or in the past 6 months

- Medications that affect the vasculature

- Overweight or other indications of insulin resistance

- Elevated LDL cholesterol > 160

- Elevated BP > 140/90

- History of congestive heart failure, ischemic heart disease, severe pulmonary disease,
liver or kidney disease, bleeding disorders

- Any vascular disease such as myocardial infarction, stroke, peripheral vascular
disease

- Presence of an intracardiac or intrapulmonary shunt (we will screen for this by
auscultation during the physical exam by PI).

- Pregnant or breastfeeding.

- Known hypersensitivity to perflutren (contained in Definity)