Overview

Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors

Status:
Withdrawn
Trial end date:
2015-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to examine the response rate of desmoid tumors to hydroxyurea. The investigators hypothesize that hydroxyurea will be a safe, non-toxic alternative to aggressive surgery or chemotherapy for this difficult to treat tumor.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Hospital of Philadelphia
Treatments:
Hydroxyurea
Criteria
Inclusion Criteria:

- Patients
- Histologically-confirmed diagnosis of desmoid tumor

- Measurable disease

- Stable hematologic, renal and hepatic parameters

- Negative pregnancy test for women of childbearing potential

Exclusion Criteria:

- Presence of a second neoplastic process

- Pregnant or breastfeeding women, fetuses, and prisoners will not be included in this
study

- Patients receiving additional treatment for tumor other than pain control

- Patients having taken an investigational drug within the past 30 days