Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-Dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease

• Status: Completed
• Trial end date: 2007-04-01

Summary

Endothelial dysfunction is an early marker of atherosclerosis and is found in patients (pts) with coronary (CAD) and peripheral artery disease (PAD). Statin-therapy has been shown to improve endothelial function in pts with CAD or PAD by reducing LDL-cholesterol and inflammatory markers. B-group vitamin-supplements have variable been reported to have positive or neutral effects on endothelial function. Therefore, we want to compare the effect of rosuvastatin and B-group vitamin supplementation on endothelial function of the forearm resistance vessels in pts with cardiovascular disease.

• Phase: Phase 2

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Folic Acid; Hydroxocobalamin; Pyridoxal; Pyridoxine; Rosuvastatin Calcium; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamins