Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Extensive clinical studies have shown that intraoperative infusion high dose of remifentanil (0.2ug/kg/min) induced postoperative hyperalgesia. Recent experimental study however suggests that higher dose of remifentanil may attenuate postoperative hyperalgesia. Thus, the present study is designed as a "proof of principle" study and hypothesizes that higher dose of remifentanil may reduce postoperative pain in patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central South University
• Treatments: Remifentanil

Criteria

Inclusion Criteria:

• ASA Grade I or II

• Age 18-60 years old

• BMI<35,

Exclusion Criteria:

• do not consent,

• Chronic pain,

• used pain killer,

• undergoing operation previously

• diabetes or the other diseases affecting the sensory.

• difficult intubation;

• unexpected surgical complication such as bleeding;

• psychiatric disorders;

• drug or alchohol abuse