Effect of High-dose Target-controlled Naloxone Infusion on Pain and Hyperalgesia During a Burn Injury
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
In several rodent studies, it has been demonstrated that very high doses of opioid
antagonists (i.e., naloxone 3-10 mg/kg) administered after weeks after recovery from an
inflammatory injury may lead to a reinstatement of hyperalgesia and pain behavior. This
latent sensitization has recently been demonstrated also to take place in humans.
The present study examines if it is possible to foresee individuals who will demonstrate a
larger degree of latent sensitization upon challenge with an injury, than others. Using an
enriched design high sensitizers (e.g., the upper quartile of individuals developing large
areas of secondary hyperalgesia following a mild burn injury) are compared with low
sensitizers (lower quartile), regarding the propensity for developing latent sensitization