Effect of High-dose Naloxone Following Third Molar Extraction
Status:
Unknown status
Trial end date:
2020-05-01
Target enrollment:
Participant gender:
Summary
Recent studies have focused on the role of endogenous opioids on central sensitization.
Central sensitization is known to be impaired or altered in chronic pain conditions, as
fibromyalgia or chronic tension headache.
Animal studies have shown reinstatement of mechanical hypersensitivity following naloxone
administration after resolution of an injury. This suggests latent sensitization. In the
present study, the investigators hypothesize that a high-dose target-controlled naloxone
infusion (total dose: 3.25 mg/kg) can reinstate pain and hyperalgesia 6-8 weeks after a
unilateral primary open groin hernia repair procedure. The investigators aim to show that
latent sensitization is present in humans and is modulated by endogenous opioids.