Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans
Status:
Completed
Trial end date:
2005-08-01
Target enrollment:
Participant gender:
Summary
Because of their antiinflamatory effects, glucocorticoids are often used to reduce edema in
neurologic tissue and to otherwise mitigate the consequences of neural inflammation. For
example, high dose prednisolone treatment has been shown to be an effective therapy for
different eye diseases including severe Graves´ Ophthalmopathy and acute optic neuritis.
However, contradictory results exists for the influence of high dose prednisolone therapy per
se on tissue blood flow. Thus, in the current study, we plan to investigate the effect of
high dose, short time therapy with intravenous prednisolone in patients with optic neuritis
and severe Graves´ Ophthalmopathy.