Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis
Status:
Not yet recruiting
Trial end date:
2025-03-31
Target enrollment:
Participant gender:
Summary
Sepsis, a life-threatening syndrome, is often accompanied by tachycardia in spite of adequate
volume resuscitation to correct hypovolemia and vasopressor medication to correct
hypotension. Recently, relevant studies have shown that sustained tachycardia in sepsis was
also related to high mortality, and appropriate control of heart rate could improve
prognosis. Ivabradine reduces heart rate directly without a negative inotropic effect through
inhibition of the If ionic current，which is absent from the traditional rate control drug
(beta-blockers). This is a prospective, multicenter, randomized, open label study designed to
compare ivabradine with placebo on the difference of heart rate and haemodynamics in patients
with sepsis.
Phase:
Phase 4
Details
Lead Sponsor:
Second Affiliated Hospital of Guangzhou Medical University