Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this research study is to learn about brain development in very young girls with Turner syndrome (TS) and the effect that growth hormone (GH) therapy has on early brain development.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Marsha Davenport, MD; Rebecca Knickmeyer Santelli, PhD
• Collaborator: Pfizer
• Treatments: Hormones

Criteria

Inclusion Criteria:

• Diagnosis of Turner syndrome

• Less than the 50th percentile for length for the general female population

Exclusion Criteria:

• Prior Growth Hormone (GH) therapy

• Diabetes

• Allergy to metacresol (a preservative in the GH liquid that is injected)

• Contraindications for Magnetic Resonance Imaging (MRI) (such as metal in the body)

• Part of a Y chromosome in child's karyotype

• Parent/guardian is not willing for child to be randomized to be in the treatment group (receives Growth Hormone injections for one year) or the control group (receives no Growth Hormone during the study)

• Parent/guardian is not willing for child to have some of her developmental testing digitally recorded for scoring