Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes mellitus (T2DM) has become the epidemic of the XXI century. This chronic
disease is also highly prevalent and primarily associated with an increased cardiovascular
mortality and morbidity due to micro and macrovascular complications, where its
pathophysiological mechanism accelerates the formation of the atherosclerotic process,
fundamental element associated with arterial stiffness. The importance of anticipating the
presence of a cardiovascular event lies precisely in the early detection of subclinical
changes in the elastic arteries identified by measuring the pulse wave velocity. Having
adequate pharmacological or non-pharmacological interventions that impact precisely in the
reduction of pulse wave velocity contributes to a reduction of cardiovascular morbidity and
mortality associated with DM2. Among non-pharmacological therapies they have been studied the
benefits attributed to the use of green tea infusion either encapsulated or extract have been
associated mainly with anti-inflammatory and antioxidant effects. There are both experimental
and clinical studies that have shown benefits of administration of green tea (extract or
infusion), and administered by different routes at different dosages and for varying times.
But it has been noted that not all studies with green tea meet appropriate to draw
conclusions about its benefits to cardiovascular level. However, it is proposed that the use
of green tea extract with a highest amount of catechins through a controlled clinical trial
could be a potential therapeutic strategy for changing hemodynamic alterations and arterial
stiffness favorably in this particular group of patients DM2.
Phase:
Phase 2
Details
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico