Effect of Goal-directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity

• Status: Completed
• Trial end date: 2017-10-20
• Target enrollment: 0
• Participant gender: All

Summary

A trial in which patients having open abdominal surgery are randomized to receive either crystalloids or colloids intraoperatively, guided by esophageal Doppler. The investigators test the primary hypothesis that goal-directed colloid administration during elective abdominal surgery decreases a composite of postoperative complications within 30 days of surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic

Criteria

Inclusion Criteria:

• ASA Physical Status 1-3

• Body Mass Index < 35

• Moderate risk elective abdominal surgical procedures scheduled to take ≥ two hours done under general anesthesia.

Exclusion Criteria:

• cardiac insufficiency (EF<35%)

• coronary disease with angina (NYHA IV)

• severe chronic obstructive pulmonary disease

• coagulopathies

• symptoms of infection or sepsis

• renal insufficiency (creatinine clearance <30ml/min or renal replacement therapy)

• ASA Physical Status > 3.