Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia

• Status: Completed
• Trial end date: 2021-01-31
• Target enrollment: 0
• Participant gender: Female

Summary

This is prospective randomised double blind study conducted in parturients planned for non-elective caesarean section under spinal anaesthesia. Glycopyrrolate group will receive 0.2 mg of Glycopyrrolate before start of phenylephrine infusion. Control group will receive 0.2 ml of Normal Saline before start of phenylephrine infusion. Total amount of vasopressors required i.e. ephedrine or phenylephrine will recorded in the form of phenylephrine equivalent during intraoperative period.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rajesh Deshar
• Treatments: Bromides; Glycopyrrolate

Criteria

Inclusion Criteria:

• Age between 18-40 years

• All parturients at term (gestational weeks ≥ 37)

• ASA (American society of Anaesthesiologist) PS (Physical status) grade II

Exclusion Criteria:

• Age >40 year

• ASA PS Grade >2

• Maternal bradycardia (baseline HR< 60/min) or tachycardia (baseline HR> 100/min)

• Pregnancy induced hypertension

• Gestational hypertension

• Known fetal abnormalities

• Intrauterine growth retardation (IUGR)

• Intrauterine fetal death (IUFD)

• Contraindications to spinal anaesthesia

• Contraindications to glycopyrrolate

• Multiple pregnancy

• BMI: > 30 kg/m2

• Height: <150cm