Effect of Glutathione on Blood Alcohol and Hangover Symptoms
Status:
Completed
Trial end date:
2005-08-01
Target enrollment:
Participant gender:
Summary
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a
great role in homeostasis, especially as a potent anti-oxidant.
As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and
excretes in urine as mercapturic acid.
In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on
blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing
effect.
The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a
correlation with hangover symptoms. This study is designed to find this correlation using
blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the
Slutske et al study.