Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)
Status:
Completed
Trial end date:
2016-05-16
Target enrollment:
Participant gender:
Summary
The primary objective of this double-blind crossover study is to assess the effect of single
doses of 50 mg and 300 mg gefapixant (AF-219/MK-7264) on cough reflex sensitivity to
capsaicin in both healthy participants and participants with chronic cough. This study will
also assess the effect of single doses of gefapixant on cough reflex sensitivity to adenosine
triphosphate (ATP) in healthy participants and participants with chronic cough.