Overview

Effect of Gabapentin on Orthopedic Pain

Status:
Terminated
Trial end date:
2016-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study is being done to determine if a drug called gabapentin helps in the postoperative management of patients undergoing hip and knee operations. The investigators wish to determine the effect of gabapentin on pain and sleep following surgery. If we can lessen a patient's pain and improve sleep, the patient will be better able to participate in their physical therapy. Gabapentin has already been shown to lessen postoperative pain when given before surgery. In healthy patients, it has also been shown to improve certain aspects of sleep. We hope to identify the effect of the drug, when given after surgery, on patients' pain and sleep.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Rutgers, The State University of New Jersey
Treatments:
Gabapentin
Criteria
Inclusion Criteria:

- Undergoing a hip arthroplasty, total knee arthroplasty, hip fracture repair American
Society of Anesthesiologist rating I-III as determined by your anesthesiologist

Exclusion Criteria:

- Pregnancy and breast feeding

- An allergy to any of the drugs to be used in the study (midazolam, Celecoxib,
gabapentin, hydromorphone, bupivacaine)

- History of a sleep disorder (Obstructive sleep apnea or daytime somnolence)

- History of taking chronic narcotic pain medications or gabapentin

- History of rheumatoid arthritis, a psychiatric disorder, or diabetes with
impaired renal function

- History of alcohol or illicit drug abuse.

- History of a kidney or liver problem.

- Inability or unwilling to use patient-controlled analgesia.

- Unable to meet the criteria for removal of the endotracheal tube in the Operating
Room

- History of asthma, hives or an allergic type reaction following an aspirin or
other NSAIDS drug such as Ibuprofen.

- History of stroke or heart attack or thrombotic event within the past 3 months

- Lactose intolerance

- History of cardiac surgery