Effect of Folic Acid on Endothelial and Baroreceptor Function in Patients With Heart Failure
Status:
Terminated
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
The randomized, double-blind, placebo-controlled study aim to evaluate the effect of 1-month
therapy with folic acid (5 mg/day) on endothelial function and baroreceptor function in
patients with heart failure.
Endothelial function will be studied non-invasively with flow-mediated dilation while for
eveluating baroreceptor function sympathetic nervous system activity will be measured
directly with microneurography in baseline condition and during infusion of
sodium-nitroprusside.