Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting. We hypothezied a positive effect of fluvastatin on platelet aggregation levels.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Aspirin; Clopidogrel; Fluvastatin

Criteria

Inclusion Criteria:

• all patients with stent implantation followed by treatment with aspirin and clopidogrel

• routinely treated with acetylsalicylic 100 mg/day

Exclusion Criteria:

• acute coronary syndrome

• use of a GPIIb/IIIa inhibitor

• allergy to acetylsalicylic acid, clopidogrel, statins

• elevated liver enzymes (> 3 x norm value)

• muscle myopathy

• active liver disease

• recent gastrointestinal bleeding (< 3 months)

• known platelet dysfunction or abnormal platelet count

• pregnancy

• indication for treatment with non-steroidal drugs

• indication for long-term treatment with a drug metabolized by cytochrome p450 3A4 or 2C9