Overview

Effect of Fluconazole on the Pharmacokinetics of Pyrotinib in Healthy Subjects

Status:
Completed

Trial end date:
2021-05-17

Target enrollment:
0

Participant gender:
All

Summary

The primary objective of the study is to evaluate the effect of fluconazole on pharmacokinetics of pyrotinib tablet for oral administration in healthy Chinese adult subjects. The secondary objective of the study is to compare the safety of pyrotinib alone and co-administered with fluconazole.

Phase:

Phase 1

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Jiangsu HengRui Medicine Co., Ltd.

Treatments:

Fluconazole

Criteria

Inclusion Criteria:

1. Participants has given written informed consent with full understanding of the trial
content, process and possible adverse reactions;

2. Ability to complete the study as required by the protocol;

3. Healthy male or female subjects aged 18 to 45 (including 18 and 45) at the date of
signing the informed consent;

4. Male body weight ≥ 50 kg, female body weight ≥ 45 kg, and body mass index (BMI) within
the range of 19 ~ 26 kg /m2 (including 19 and 26);

5. Willing to take contraception or male subjects who can guarantee not to donate sperm
during the trial and within 6 months after the last dose; female subjects with
fertility who did not use contraception for at least 2 weeks before dosing;

Exclusion Criteria:

1. Allergic constitution or Allergic to a drug ingredient or component;

2. History of drug use, or drug abuse screening positive;

3. Alcoholic or often drinkers;

4. Left ventricular ejection fraction (LVEF) <50% by echocardiography;

5. A clear medical history of important primary organ diseases such as nervous system,
cardiovascular system, urinary system, digestive system, respiratory system,
metabolism and musculoskeletal system;

6. Abnormal clinical laboratory tests and clinical significance judged by the
investigator or other clinical findings showing the following diseases, including but
not limited to gastrointestinal tract, kidney, liver, nerve, blood, endocrine, tumor,
lung, immune, mental or cardiovascular and cerebrovascular diseases;

7. Participated in a clinical trial and has received an investigational product within 3
months prior to the first dosing day in the current study;

8. Positive value of HBsAg、HCV-Ab、HIV-Ab、TPPA at screening；

9. Blood loss ≥400mL within 3 months before first dosing;

10. Patients who had a positive blood pregnancy test and were breastfeeding at the time of
screening.

11. The investigators determined that other conditions were inappropriate for
participation in this clinical trial .