Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

• Status: Recruiting
• Trial end date: 2022-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Researchers are trying to determine how changes in fasting glucose and free fatty acids (products released from fat) affect insulin secretion.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Insulin; Insulin, Globin Zinc; Somatostatin; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria

• Weight-stable, non-diabetic subjects from Biobank participants at Mayo Clinic, Rochester

Exclusion Criteria

• Age < 25 or > 65 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).

• HbA1c ≥ 6.5%

• Use of glucose-lowering agents.

• For female subjects: positive pregnancy test at the time of enrollment or study

• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.

• Active systemic illness or malignancy.

• Symptomatic macrovascular or microvascular disease.

• Hormone replacement therapy >0.625 mg premarin daily