Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation
Status:
Completed
Trial end date:
2007-08-01
Target enrollment:
Participant gender:
Summary
The aim of our study is to Estimate the reduction of LDL by ezetimibe in hypercholesterolemic
patients on simvastatin.Investigate the effect of LDL lowering by ezetimibe on platelet
activity and LDL tendency to peroxidation in hypercholesterolemic patients on simvastatin
therapy
The hypothesis is that:
1. LDL lowering by ezetimibe on-top of simvastatin in patients on fixed dose of simvastatin
can reduce platelet aggregation, due to the potential decreasing of cholesterol content
in the platelet membranes.
2. LDL lowering by ezetimibe can lower LDL tendency to peroxidation.