Effect of Exogenous Lactate on Neurocognitive in Brain Trauma
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
Mild traumatic brain injury (TBI) is the most common type of brain injury. Post-mild TBI
disability could stem from cognitive, physical, psychological and social dysfunction which
resulted in significant disability and unemployment. Long-term behavioral impairments which
affected the individual's occupation, lifestyle, and family frequently occurred in
individuals with mild to moderate brain injuries who physically fully recovered. In-vitro and
in-vivo studies showed a better recovery of cognitive function after administration of
exogenous lactate in traumatic brain injury. Therefore, this study is aimed to evaluate the
effect of exogenous lactate infusion contained in hyperosmolar sodium lactate solution on
cognitive function assessed by Mini Mental State Examination(MMSE)scale.