Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging
Status:
Unknown status
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
Indocyanine Green (ICG) lymphography is a relatively new imaging technique that allows for
quick visualization of superficial lymph flow in real-time, without radiation exposure. This
imaging is useful for diagnosing and assessing lymphedema. ICG lymphography has a higher
sensitivity and specificity than lymphoscintigraphy, the current gold standard imaging device
for lymphedema. ICG lymphography precisely and reliably diagnoses, tracks, and stages
lymphedema severity, ranging from subclinical or early lymphedema to more advanced cases. The
ICG contrast dye used to visualize the lymphatic system takes approximately six hours to
plateau. Therefore, patients must wait six hours between their initial and delayed scans.
The purpose of this study is to determine if exercising on a Nu-step device between ICG
initial and delayed scans would shorten the period of time a patient had to spend at the
hospital on the day of their ICG lymphography.
The general procedures for this involve (after selecting subjects, consenting subjects,
educating the subject on the protocol, along with other appropriate measures):
- Taking baseline vitals (HR & SpO2) and limb circumference measurements
- 5-minute period of time to acquaint subject with the exercise equipment (Nu-Step) at any
level of exertion
- injection of contrast agent to allow for visualization of the superficial lymphatic
system by a qualified nurse
- Initial scan
- A 5-minute period of exercise at "moderate" level of exercise (This correlates to the
rating of perceived exertion levels of 12-13; All exercise periods should be at this
level and will be monitored by a provider)
- Second scan & vitals
- 5-minute period of exercise
- Third scan & vitals
o Continue 5-minute exercise period followed by scan & vitals until disease pattern
emerges
* Exercise for 5 minutes then scan and vitals until images reach steady state for two
consecutive scans
- Final vitals (HR & SpO2)
* Repeat scan every 1 hour until the normal 6 hour scan to monitor for further changes
in lymphatic pattern.
- Exit survey