Effect of Estrogen Therapy on Objective Sleep Quality in Postmenopausal Women
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
1. Sex hormone including estrogen have synergistic effect to serotonin activity and
decrease activity of monoamine oxidase activity so the norepinephrine is not be
metabolized, these substance are important to regulate hemostasis and circadian process
of sleep
2. Estrogen also regulate gamma-aminobutyric acid (GABA) secretion
- GABA substance is in order to initiate sleep and continue sleep
3. According to epidemiologic data, problem of sleep was increasing in postmenopause group
compare to premenopause group (aged-match)
4. This research perform to find out the actual effect of estrogen in improving sleep
quality.