Effect of Esomeprazole 40 mg.Daily for 7 Days on Acid Reflux and Related Arousals During Sleep in Patients With GERD

• Status: Unknown status
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if esomeprazole 40 mg. once daily improves not only nighttime symptoms but also significantly reduces conscious awakenings associated with gastroesophageal reflux and consequently improves sleep quality.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southern Arizona VA Health Care System
• Treatments: Esomeprazole

Criteria

Inclusion Criteria:

• Nocturnal symptoms at least twice a week.

• Ages 18-80

• Erosive esophagitis and/or abnormal pH test -

• Able to read, understand, and complete study questionnaires

Exclusion Criteria:

• Subjects with Barrett's esophagus or peptic stricture on endoscopy

• Subjects with normal endoscopy and pH test

• Subjects with previous upper gastrointestinal surgery